Postgraduate medical journal · 2026
Systemic inflammatory markers and epicardial fat volume as predictors of cardiometabolic risk in type 2 diabetes.
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Cosgun Mehmet, Cosgun Zeliha, Kalfaoglu Melike Elif, Aktas Gulali
Аннотация
BACKGROUND: This study aims to examine the relationship between markers indicating systemic inflammatory response and epicardial fat volume (EFV) detected by computed tomography (CT) in type 2 diabetes mellitus (T2DM) patients.
METHODS: A total of 165 patients (92 patients with diabetes and 73 control group) who underwent thoracic CT examination were included in the study. Hemogram parameters, lipid profiles, HbA1c, glucose, C-reactive protein, and uric acid levels were recorded. The systemic inflammatory response was calculated using the formula P × N/L. CT images were analysed by an experienced radiologist using 3D Slicer software.
RESULTS: EFV and surface area were significantly higher in T2DM patients compared to the control group (P < .001). Additionally, the uric acid to HDL ratio (UHR) and systemic inflammatory index (SII) values of T2DM patients were significantly higher than those of control subjects (P = .04 for UHR and P = .035 for SII). Receiver operating characteristic analysis showed that EFV was >15.5 in T2DM patients with a sensitivity of 92% and a specificity of 37%.
CONCLUSIONS: This study reveals that EFV is higher in T2DM patients and shows a positive correlation SII. Evaluating EFV, SII, and UHR together may be significant in assessing the inflammatory burden and cardiac risk of T2DM. The ease and cost-effectiveness of these markers increase their usability in clinical practice. Key messages What is already known on this topic: Epicardial fat volume (EFV) and systemic inflammatory index (SII) have been reported to be associated with type 2 diabetes mellitus (T2DM). What this study adds: Besides correlated with SII, EFV was further associated with T2DM and high sensitivity in detecting diabetic subjects. How this study might affect research, practice, or policy: The results of the present study may guide clinicians in personalizing preventive strategies, such as, identifying patients at higher cardiometabolic risk who could benefit from intensive lifestyle or pharmacological interventions.
METHODS: A total of 165 patients (92 patients with diabetes and 73 control group) who underwent thoracic CT examination were included in the study. Hemogram parameters, lipid profiles, HbA1c, glucose, C-reactive protein, and uric acid levels were recorded. The systemic inflammatory response was calculated using the formula P × N/L. CT images were analysed by an experienced radiologist using 3D Slicer software.
RESULTS: EFV and surface area were significantly higher in T2DM patients compared to the control group (P < .001). Additionally, the uric acid to HDL ratio (UHR) and systemic inflammatory index (SII) values of T2DM patients were significantly higher than those of control subjects (P = .04 for UHR and P = .035 for SII). Receiver operating characteristic analysis showed that EFV was >15.5 in T2DM patients with a sensitivity of 92% and a specificity of 37%.
CONCLUSIONS: This study reveals that EFV is higher in T2DM patients and shows a positive correlation SII. Evaluating EFV, SII, and UHR together may be significant in assessing the inflammatory burden and cardiac risk of T2DM. The ease and cost-effectiveness of these markers increase their usability in clinical practice. Key messages What is already known on this topic: Epicardial fat volume (EFV) and systemic inflammatory index (SII) have been reported to be associated with type 2 diabetes mellitus (T2DM). What this study adds: Besides correlated with SII, EFV was further associated with T2DM and high sensitivity in detecting diabetic subjects. How this study might affect research, practice, or policy: The results of the present study may guide clinicians in personalizing preventive strategies, such as, identifying patients at higher cardiometabolic risk who could benefit from intensive lifestyle or pharmacological interventions.