Japanese journal of radiology · 2012
Assessment of radiation dermatitis using objective analysis for patients with breast cancer treated with breast-conserving therapy: influence of body weight.
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Yamazaki Hideya, Yoshida Ken, Kobayashi Kana, Tsubokura Takuji, Kodani Naohiro, Aibe Norihiro, Ikeno Hiroyasu, Nishimura Takuya
Аннотация
PURPOSE: To evaluate the effect of patient factors on radiation dermatitis for patients with breast cancer who underwent postoperative radiotherapy after breast-conserving surgery.
MATERIALS AND METHODS: The study population comprised 87 patients who underwent breast-conserving surgery followed by 50 Gy/25 fractions (median) of radiotherapy with or without boost radiation (10 Gy/5 fractions). We examined their treated and contralateral breast skin color by use of an objective analyzer, and expressed findings as L, a, b ratios by dividing by pre-RT values. Next, we examined correlation between patient factors (age, height, body weight, and body mass index, BMI) and change of L and a values by use of correlation coefficients.
RESULTS: Radiation therapy caused changes in a and L ratios (p < 0.0001) but not in b ratio. The a ratio (reddish) increased 1.4-fold and peaked after radiotherapy. The L ratio (darkening) decreased by 10 % and reached a minimum value between completion of radiotherapy and 1 month after treatment. Although, age and height did not affect Δ value, body weight and BMI correlated significantly with Δa value (p = 0.0012 and 0.0017) not with ΔL value.
CONCLUSION: Body weight and BMI predict degree of radiation dermatitis, and more reddish dermatitis was observed for heavier patients than for their lighter counterparts.
MATERIALS AND METHODS: The study population comprised 87 patients who underwent breast-conserving surgery followed by 50 Gy/25 fractions (median) of radiotherapy with or without boost radiation (10 Gy/5 fractions). We examined their treated and contralateral breast skin color by use of an objective analyzer, and expressed findings as L, a, b ratios by dividing by pre-RT values. Next, we examined correlation between patient factors (age, height, body weight, and body mass index, BMI) and change of L and a values by use of correlation coefficients.
RESULTS: Radiation therapy caused changes in a and L ratios (p < 0.0001) but not in b ratio. The a ratio (reddish) increased 1.4-fold and peaked after radiotherapy. The L ratio (darkening) decreased by 10 % and reached a minimum value between completion of radiotherapy and 1 month after treatment. Although, age and height did not affect Δ value, body weight and BMI correlated significantly with Δa value (p = 0.0012 and 0.0017) not with ΔL value.
CONCLUSION: Body weight and BMI predict degree of radiation dermatitis, and more reddish dermatitis was observed for heavier patients than for their lighter counterparts.