The use of sodium hyaluronate for the treatment of radiation recall dermatitis.

Hyaluronic acid (HA) is a high-molecular weight polysaccharide, a glycosaminoglycan that enhances fibroblast movement and metabolism during wound healing, increasing collagen fibers forming granulation tissue. We describe a 42-year-old female, who developed radiation recall dermatitis following an allogeneic stem cell transplant from an unrelated donor (MUD-PBSCT). Her skin was treated with a topical sodium hyaluronate gel twice daily (RadiaplexRX, MPM Medical). There was marked improvement after 5 days of therapy without discontinuation of any of her therapeutic agents. At a time when the health care providers were faced with considerable treatment dilemmas, this patient demonstrated improvement in the symptoms of radiation recall dermatitis with the topical application of sodium hyaluronate and no change in her medication profile. This agent could successfully allow practitioners to treat radiation recall dermatitis without discontinuation of the recall trigger drug and thus jeopardizing the outcome of the treatment regimen.