Sensitization to isothiazolinones in the Spanish Contact Dermatitis Registry (REIDAC): 2019-2021 epidemiological situation.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Hernández Fernández Carlos Pelayo, Borrego Leopoldo, Mercader García Pedro, Giménez Arnau Ana María, Sánchez Pérez Javier, Silvestre Salvador Juan Francisco, González Pérez Ricardo, Sanz Sánchez Tatiana, Sánchez Gilo Araceli, Melé Ninot Gemma, Zaragoza Ninet Violeta, Miquel Miquel Francisco Javier, Carrascosa Carrillo José Manuel, Córdoba Guijarro Susana, Gatica Ortega María Elena, Ruiz González Inmaculada, Serra Baldrich Esther, Tous Romero Fátima, Rodríguez Serna Mercedes, Pastor Nieto María Antonia, Pérez Feal Patricia, Hervella Garcés Marcos, de Vega Martínez Marina, García Doval Ignacio
Аннотация
OBJECTIVES: To study the frequency of sensitization, risk factors and simultaneous sensitization between the four isothiazolinones.
MATERIALS AND METHODS: We analysed all 2019-2021 consecutive patients patch-tested with MI (0.2% aq.), MCI/MI (0.02% aq.), BIT (0.1% pet.) and OIT (0.1% pet) within the Spanish Contact Dermatitis Registry (REIDAC).
RESULTS: A total of 2511 patients were analysed. Frequencies of sensitization were: any isothiazolinone 15.7%, MI 6.8%, MCI/MI 4.8%, BIT 3.5% and OIT 0.5%. MI and MCI/MI sensitization was associated with being occupationally active, hand dermatitis, detergents and age over 40. BIT sensitization was associated with leg dermatitis and age over 40. About one in nine MI-positive patients were positive to BIT, whereas one in five BIT-positive patients were positive to MI.
CONCLUSIONS: Sensitization to MI, MCI/MI and BIT is still common in Spain, while sensitization to OIT is rare. Currently, sensitization to MI and MCI/MI seems to be occupationally related. Although its origin is unknown, sensitization to BIT is more frequent in patients aged over 40 years. Simultaneous sensitization between MI and BIT is uncommon.