Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
Patterns of Multimorbidity among Older Adults with Colorectal Cancer Living in Puerto Rico.
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Castañeda-Avila Maira A, Gierbolini-Bermúdez Axel J, Baek Jonggyu, Ortiz-Ortiz Karen J, Alavi Karim, Lapane Kate L
Аннотация
BACKGROUND: Multimorbidity among Hispanic patients with colorectal cancer in Puerto Rico remains poorly understood despite their potential impact on patient outcomes. We examined patterns of chronic conditions at colorectal cancer diagnosis and their associations with sociodemographic factors, stage at diagnosis, and tumor location.
METHODS: We used the Puerto Rico Central Cancer Registry-Health Insurance Linkage Database (2012-2020). Adults ≥50 years of age with a first colorectal cancer diagnosis were included. Chronic conditions were identified using Medicare and Medicaid Chronic Conditions Data Warehouse algorithms. Latent class analysis and regression models assessed multimorbidity patterns and associations with sociodemographic and tumor characteristics.
RESULTS: Among 6,543 adults with colorectal cancer (mean age, 67.7 years; 45.7% female), 52.7% had no additional chronic conditions, 18.7% had 1, and 28.6% had ≥2 conditions. The most prevalent comorbidities were hypertension (20.6%), diabetes (14.4%), and hyperlipidemia (12.2%). Three multimorbidity patterns were identified: hypertensive-vision-joint, diabetic renal, and cardiopulmonary severe. Advanced age, female sex, and Medicare insurance predicted class membership. Older age was associated with membership in the cardiopulmonary severe group [adjusted prevalence ratio (aPR) = 1.75 for ages 76-85 years; aPR = 2.86 for ≥86 years]. Females were more likely to belong to the hypertensive-vision-joint group (aPR = 1.42). Multimorbidity patterns were not associated with tumor location or stage at diagnosis.
CONCLUSIONS: Multimorbidity is common among older Hispanic adults with colorectal cancer in Puerto Rico and forms distinct patterns associated with sociodemographic factors, highlighting heterogeneity in medical complexity.
IMPACT: Identifying multimorbidity patterns among older patients with colorectal cancer in Puerto Rico underscores the need for integrated, patient-centered care for aging Hispanics.
METHODS: We used the Puerto Rico Central Cancer Registry-Health Insurance Linkage Database (2012-2020). Adults ≥50 years of age with a first colorectal cancer diagnosis were included. Chronic conditions were identified using Medicare and Medicaid Chronic Conditions Data Warehouse algorithms. Latent class analysis and regression models assessed multimorbidity patterns and associations with sociodemographic and tumor characteristics.
RESULTS: Among 6,543 adults with colorectal cancer (mean age, 67.7 years; 45.7% female), 52.7% had no additional chronic conditions, 18.7% had 1, and 28.6% had ≥2 conditions. The most prevalent comorbidities were hypertension (20.6%), diabetes (14.4%), and hyperlipidemia (12.2%). Three multimorbidity patterns were identified: hypertensive-vision-joint, diabetic renal, and cardiopulmonary severe. Advanced age, female sex, and Medicare insurance predicted class membership. Older age was associated with membership in the cardiopulmonary severe group [adjusted prevalence ratio (aPR) = 1.75 for ages 76-85 years; aPR = 2.86 for ≥86 years]. Females were more likely to belong to the hypertensive-vision-joint group (aPR = 1.42). Multimorbidity patterns were not associated with tumor location or stage at diagnosis.
CONCLUSIONS: Multimorbidity is common among older Hispanic adults with colorectal cancer in Puerto Rico and forms distinct patterns associated with sociodemographic factors, highlighting heterogeneity in medical complexity.
IMPACT: Identifying multimorbidity patterns among older patients with colorectal cancer in Puerto Rico underscores the need for integrated, patient-centered care for aging Hispanics.