Public health nutrition · 2011
Visual acuity in fish consumers of the Brazilian Amazon: risks and benefits from local diet.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Fillion Myriam, Lemire Mélanie, Philibert Aline, Frenette Benoît, Weiler Hope Alberta, Deguire Jason Robert, Guimarães Jean Remy Davée, Larribe Fabrice, Barbosa Fernando, Mergler Donna
Аннотация
OBJECTIVE: To examine the associations between near and distant visual acuity and biomarkers of Hg, Pb, n-3 fatty acids and Se from the local diet of fish-eating communities of the Tapajós River in the Brazilian Amazon.
DESIGN: Visuo-ocular health and biomarkers of Hg (hair, whole blood, plasma), Pb (whole blood), Se (whole blood and plasma) and n-3 fatty acids (plasma total phospholipids) were assessed in a cross-sectional study.
SETTING: Lower Tapajós River Basin (State of Pará, Brazil), May to July 2006.
SUBJECTS: Two hundred and forty-three adults (≥15 years) without diagnosed age-related cataracts or ocular pathologies.
RESULTS: Near visual acuity was negatively associated with hair Hg and positively associated with %DHA, with a highly significant Log Hg × age interaction term. Stratifying for age showed that while young people presented good acuity, for those aged ≥40 years, clinical presbyopia was associated with hair Hg ≥ 15 μg/g (OR = 3·93, 95% CI 1·25, 14·18) and %DHA (OR = 0·37, 95% CI 0·11, 1·11). A similar age-related pattern was observed for distant visual acuity in relation to blood Pb, but the evidence was weaker.
CONCLUSIONS: These findings suggest that Hg and Pb may affect visual acuity in older persons, while DHA appears to be protective for near visual acuity loss. In this population, with little access to eye care, diet may have an important influence on visuo-ocular ageing.
DESIGN: Visuo-ocular health and biomarkers of Hg (hair, whole blood, plasma), Pb (whole blood), Se (whole blood and plasma) and n-3 fatty acids (plasma total phospholipids) were assessed in a cross-sectional study.
SETTING: Lower Tapajós River Basin (State of Pará, Brazil), May to July 2006.
SUBJECTS: Two hundred and forty-three adults (≥15 years) without diagnosed age-related cataracts or ocular pathologies.
RESULTS: Near visual acuity was negatively associated with hair Hg and positively associated with %DHA, with a highly significant Log Hg × age interaction term. Stratifying for age showed that while young people presented good acuity, for those aged ≥40 years, clinical presbyopia was associated with hair Hg ≥ 15 μg/g (OR = 3·93, 95% CI 1·25, 14·18) and %DHA (OR = 0·37, 95% CI 0·11, 1·11). A similar age-related pattern was observed for distant visual acuity in relation to blood Pb, but the evidence was weaker.
CONCLUSIONS: These findings suggest that Hg and Pb may affect visual acuity in older persons, while DHA appears to be protective for near visual acuity loss. In this population, with little access to eye care, diet may have an important influence on visuo-ocular ageing.
Предметные рубрики MeSH
AdolescentAdultAgedAnimalsBiomarkersBrazilCross-Sectional StudiesDietEnvironmental MonitoringFatty Acids, Omega-3FemaleFishesFood ContaminationHairHumansLeadLogistic ModelsMaleMercuryMiddle AgedMultivariate AnalysisRisk AssessmentRiversSeleniumSocioeconomic FactorsVisual AcuityWater Pollutants, ChemicalYoung Adult