The British journal of ophthalmology · 2011
Viscoelastic properties of fresh human lenses under 40 years of age: implications for the aetiology of presbyopia.
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Schachar Ronald A, Chan Roger W, Fu Min
Аннотация
AIM: To determine the viscoelastic properties of fresh human lenses obtained from cadavers under 40 years of age.
METHODS: 52 intact clear, human lenses were obtained from 26 donors (mean age of 27.5 ± 9.2 years) within 9 ± 4 h of death. The viscoelastic properties of the lens nuclei and 16 of the lens cortices were quantified within 42 ± 10 h of death using a controlled-strain, linear, simple-shear rheometer.
RESULTS: The means (± SD) of the viscoelastic properties of the lens nuclei at a frequency of 75 Hz were: elastic shear modulus, G'=11.00 ± 4.67 Pa, viscous shear modulus, G''=24.91 ± 10.98 Pa, magnitude of the complex shear modulus, |G*|=27.23 Pa, dynamic viscosity, η'=0.33 Pa.s, damping ratio, ζ=2.26 and phase shift, δ=66.17°. There was no statistical difference in these measures between the lens cortices and their respective lens nuclei. There was a small age-related statistically significant increase in G', p=0.003, but not G'' or |G*|.
CONCLUSIONS: The observed age-related increase in tissue stiffness of the lens nucleus, ~0.4 Pa/year, is too small to account for the 10 dioptre decline in accommodative amplitude in this age group.
METHODS: 52 intact clear, human lenses were obtained from 26 donors (mean age of 27.5 ± 9.2 years) within 9 ± 4 h of death. The viscoelastic properties of the lens nuclei and 16 of the lens cortices were quantified within 42 ± 10 h of death using a controlled-strain, linear, simple-shear rheometer.
RESULTS: The means (± SD) of the viscoelastic properties of the lens nuclei at a frequency of 75 Hz were: elastic shear modulus, G'=11.00 ± 4.67 Pa, viscous shear modulus, G''=24.91 ± 10.98 Pa, magnitude of the complex shear modulus, |G*|=27.23 Pa, dynamic viscosity, η'=0.33 Pa.s, damping ratio, ζ=2.26 and phase shift, δ=66.17°. There was no statistical difference in these measures between the lens cortices and their respective lens nuclei. There was a small age-related statistically significant increase in G', p=0.003, but not G'' or |G*|.
CONCLUSIONS: The observed age-related increase in tissue stiffness of the lens nucleus, ~0.4 Pa/year, is too small to account for the 10 dioptre decline in accommodative amplitude in this age group.