Reproducible Temperament Profiles in Adolescents With Attention-Deficit/Hyperactivity Disorder Prospectively Predict Clinical Outcomes.

Currently, the field faces controversy about how to integrate novel, trait-based dimensions into existing psychological diagnostic frameworks. The problem is salient for attention-deficit/hyperactivity disorder (ADHD), which encompasses a partially coherent neurodevelopmental syndrome that is nonetheless heterogeneous with respect to mechanism and outcomes. Here, we suggest that temperament profiles, related to trait-based variation in emotional response and regulation, provide a viable way to link the complexity of within-group trait variation to differences in clinical outcomes. Across two large, independent samples of adolescents with ADHD (Oregon ADHD-1000, ABCD) we identified largely reproducible temperament profiles: a high approach motivation profile ("Surgent") and a high negative emotion profile ("Irritable"). In both samples, the Irritable profile prospectively predicted worsening clinical outcomes over multiple years of longitudinal follow-up. Temperament profiling approaches can contribute to improved risk/resilience prediction among individuals with ADHD and help bridge dimensional models of psychopathology with developmental process and clinical decision-making.