Internal medicine (Tokyo, Japan) · 2012
Successful management of obstructive jaundice due to gallstones with eculizumab in a patient with paroxysmal nocturnal hemoglobinuria.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Kawano Hiroki, Minagawa Kentaro, Wakahashi Kanako, Kawano Yuko, Sada Akiko, Matsui Toshimitsu, Hirano Hirotaka, Shiomi Hideyuki, Ku Yonson, Katayama Yoshio
Аннотация
Paroxysmal nocturnal hemoglobinuria (PNH) makes patients susceptible to intravascular hemolysis and thrombosis, and it can be life-threatening in stressful situations. Eculizumab, a humanized monoclonal antibody that inhibits the complement protein C5, has been evaluated as a novel therapy for PNH. We herein describe the case of a 59-year-old Japanese woman with classic PNH, who had been successfully treated with eculizumab, but who later developed acute cholecystitis/cholangitis from gallstones. Although the severe obstructive jaundice requiring endoscopic therapy following cholecystectomy was complicated, critical intravascular hemolysis and thrombosis were not observed. Therefore, utilizing eculizumab during the peri-operative management of PNH patients should be carefully taken into consideration.