American journal of translational research · 2021
Effect of glucocorticoids infiltration on CRSwNP after endoscopic sinus surgery and the curative efficacy of nasal ventilation function and mucociliary clearance.
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Ma Shanchun, Lei Xiaoping, Tu Jing, Tian Cuiling, Lian Gang, Li Wei, Wang Dingsong
Аннотация
OBJECTIVES: This study investigated and analyzed the effects of glucocorticoid infiltration on chronic rhino-sinusitis with nasal polyps (CRSwNP) after endoscopic sinus surgery (ESS) and its curative efficacy on nasal ventilation function and mucociliary clearance (MCC).
METHODS: 126 CRSwNP patients admitted to the hospital from March 2018 to May 2020 were enrolled and randomly divided into observation group (n=65) and control group (n=61) based on random number table. The control group received ESS, and the observation group was given glucocorticoids treatment after ESS. The changes of nasal ventilation function, MCC and quality of life between the two groups of patients before and after treatment were compared.
RESULTS: The overall effective rate of clinical therapy was critically higher in observation group than in control group (P<0.05). In addition, NMCA and NCV in observation group were critically higher than those in control group (P<0.05), and nasal airway resistance (NAR) in observation group was notably lower than that in control group (P<0.05). In addition, the Saccharin removal time in observation group after treatment was remarkably lower than that in control group (P<0.05), while the speed and rate of MCC were critically higher than those in control group (P<0.05). Finally, the scores of each dimension of WHOQOL-100 scale in two groups of subjects after treatment were critically higher than those before treatment (P<0.05), and the scores in observation group were notably higher than those in control group (P<0.05).
CONCLUSION: The treatment of glucocorticoid infiltration on CRSwNP after ESS can effectively improve the curative effect. It improves the patient's function of nasal ventilation and MCC, thus beneficial to promoting the sufferers' living quality and is worthy of clinical promotion.
METHODS: 126 CRSwNP patients admitted to the hospital from March 2018 to May 2020 were enrolled and randomly divided into observation group (n=65) and control group (n=61) based on random number table. The control group received ESS, and the observation group was given glucocorticoids treatment after ESS. The changes of nasal ventilation function, MCC and quality of life between the two groups of patients before and after treatment were compared.
RESULTS: The overall effective rate of clinical therapy was critically higher in observation group than in control group (P<0.05). In addition, NMCA and NCV in observation group were critically higher than those in control group (P<0.05), and nasal airway resistance (NAR) in observation group was notably lower than that in control group (P<0.05). In addition, the Saccharin removal time in observation group after treatment was remarkably lower than that in control group (P<0.05), while the speed and rate of MCC were critically higher than those in control group (P<0.05). Finally, the scores of each dimension of WHOQOL-100 scale in two groups of subjects after treatment were critically higher than those before treatment (P<0.05), and the scores in observation group were notably higher than those in control group (P<0.05).
CONCLUSION: The treatment of glucocorticoid infiltration on CRSwNP after ESS can effectively improve the curative effect. It improves the patient's function of nasal ventilation and MCC, thus beneficial to promoting the sufferers' living quality and is worthy of clinical promotion.