Journal of perinatology : official journal of the California Perinatal Association · 2026
Rates and predictors of intraventricular hemorrhage in the ventfirst trial with comparison to a contemporaneous cohort.
СтатьяМногоцентровое исследованиеРандомизированное исследованиеСравнительное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Strand Marya L, Bulas Dorothy I, Niermeyer Susan, Fang Jennifer L, Warren Jamie B, Josephsen Justin B, Epelman Monica, Kline-Fath Beth M, Petroni Gina R, Fairchild Karen D
Аннотация
OBJECTIVE: Describe rates of intraventricular hemorrhage (IVH) in the VentFirst cohort, model risks for severe IVH and compare IVH rates to a contemporaneous population.
STUDY DESIGN: Sub-analysis of the VentFirst multi-center randomized trial.
RESULTS: Head ultrasound findings from 548 infants <29 weeks' gestation who survived to first head ultrasound study in the VentFirst trial were analyzed. Any grade of IVH was found in 31% and severe (grade III/ IV) IVH in 8%. Logistic regression indicated gestational age (GA), twin gestation and 1-minute Apgar as risks for severe IVH. Odds of any IVH and severe IVH were lower in the VentFirst population than in a comparable population in the Vermont Oxford Network.
CONCLUSION: Severe IVH in the VentFirst trial was associated with low GA, twin gestation and low 1-minute Apgar score. The lower odds of IVH for the study cohort compared to a similar population may reflect optimized delivery conditions.
TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02742454.
STUDY DESIGN: Sub-analysis of the VentFirst multi-center randomized trial.
RESULTS: Head ultrasound findings from 548 infants <29 weeks' gestation who survived to first head ultrasound study in the VentFirst trial were analyzed. Any grade of IVH was found in 31% and severe (grade III/ IV) IVH in 8%. Logistic regression indicated gestational age (GA), twin gestation and 1-minute Apgar as risks for severe IVH. Odds of any IVH and severe IVH were lower in the VentFirst population than in a comparable population in the Vermont Oxford Network.
CONCLUSION: Severe IVH in the VentFirst trial was associated with low GA, twin gestation and low 1-minute Apgar score. The lower odds of IVH for the study cohort compared to a similar population may reflect optimized delivery conditions.
TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02742454.