Journal of the European Academy of Dermatology and Venereology : JEADV · 2003
Lichen planus and leukocytoclastic vasculitis induced by interferon alpha-2b in a subject with HCV-related chronic active hepatitis.
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Pinto J M de Sousa, Marques M Sacramento, Correia T Estanislau
Аннотация
Lichen planus (LP) has been reported in association with chronic active hepatitis, primary biliary cirrhosis and other chronic liver diseases. The occurrence of LP in persons with hepatitis C virus (HCV) was reported by Robert et al., and the possible relationship between LP and hepatitis virus has also been supported by cases of LP following hepatitis B vaccination. Exacerbation or appearance of LP during the treatment of chronic hepatitis C, lymphoproliferative diseases and melanoma with alpha-interferon (IFN-alpha) and improvement of these diseases after discontinuation of this drug indicate that IFN-alpha may possibly induce LP. We present a case of cutaneo-mucous LP in a woman with chronic active hepatitis treated with IFN-alpha and in whom local leukocytoclastic vasculitis was induced by the intradermal injection of a very low dose of IFN-alpha.