Cell death & disease · 2020
Metabolic defects in splenic B cell compartments from patients with liver cirrhosis.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Huang Man, Liu Xiaoju, Ye Haocheng, Zhao Xin, Zhao Juanjuan, Liu Yang, He Xiaomeng, Qu Mengmeng, Pan Jing, Hou Baidong, Cheng Yongqian, Liu Zhenwen, Li Zhiwei, Liu Lei, Sun Jian, Zhang Shuye, Zhang Zheng
Аннотация
Liver cirrhosis is associated with defective vaccine responses and increased infections. Dysregulated B cell compartments in cirrhotic patients have been noticed but not well characterized, especially in the spleen. Here, we comprehensively investigated B cell perturbations from the spleens and peripheral blood of cirrhotic patients. We found that liver cirrhosis significantly depleted both switched and nonswitched splenic memory B cells, which was further confirmed histologically. Bulk RNA-seq revealed significant metabolic defects as the potential mechanism for the impaired splenic B cell functions. Functionally, the splenic memory B cells from cirrhotic patients showed strong metabolic defects and reduced proliferation compared with those from healthy controls. Thus, liver cirrhosis extensively disturbs the splenic and peripheral B cell compartments, which may contribute to defective humoral immunity during liver cirrhosis.