Biomarkers in medicine · 2021
Whole blood viscosity in the evaluation of thrombogenic milieu in mitral stenosis.
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H Ozcan Cetin Elif, S Cetin Mehmet, B Ozbay Mustafa, C Könte Hasan, M Yaman Nezaket, A Erdöl Mehmet, Ozcan Fırat, Cay Serkan, Ozeke Ozcan, Akçay Burak, Tufekcioğlu Omac, Aras Dursun, Topaloglu Serkan
Аннотация
Aim: We aimed to assess the association of whole blood with thromboembolic milieu in significant mitral stenosis patients. Methodology & results: We included 122 patients and classified patients into two groups as having thrombogenic milieu, thrombogenic milieu (+), otherwise patients without thrombogenic milieu, thrombogenic milieu (-). Whole blood viscosity (WBV) in both shear rates were higher in thrombogenic milieu (+) group comparing with thrombogenic milieu (-). WBV at high shear rate and WBV at low shear rate parameters were moderately correlated with grade of spontaneous echo contrast. Adjusted with other parameters, WBV parameters at both shear rates were associated with presence of thrombogenic milieu. Discussion & conclusion: We found that extrapolated WBV at both shear rates was significantly associated with the thrombogenic milieu in mitral stenosis. This easily available parameter may provide additional perspective about thrombogenic diathesis.