Transcatheter Mitral Valve Replacement After Surgical Repair or Replacement: Comprehensive Midterm Evaluation of Valve-in-Valve and Valve-in-Ring Implantation From the VIVID Registry.
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Simonato Matheus, Whisenant Brian, Ribeiro Henrique Barbosa, Webb John G, Kornowski Ran, Guerrero Mayra, Wijeysundera Harindra, Søndergaard Lars, De Backer Ole, Villablanca Pedro, Rihal Charanjit, Eleid Mackram, Kempfert Jörg, Unbehaun Axel, Erlebach Magdalena, Casselman Filip, Adam Matti, Montorfano Matteo, Ancona Marco, Saia Francesco, Ubben Timm, Meincke Felix, Napodano Massimo, Codner Pablo, Schofer Joachim, Pelletier Marc, Cheung Anson, Shuvy Mony, Palma José Honório, Gaia Diego Felipe, Duncan Alison, Hildick-Smith David, Veulemans Verena, Sinning Jan-Malte, Arbel Yaron, Testa Luca, de Weger Arend, Eltchaninoff Helene, Hemery Thibault, Landes Uri, Tchetche Didier, Dumonteil Nicolas, Rodés-Cabau Josep, Kim Won-Keun, Spargias Konstantinos, Kourkoveli Panagiota, Ben-Yehuda Ori, Teles Rui Campante, Barbanti Marco, Fiorina Claudia, Thukkani Arun, Mackensen G Burkhard, Jones Noah, Presbitero Patrizia, Petronio Anna Sonia, Allali Abdelhakim, Champagnac Didier, Bleiziffer Sabine, Rudolph Tanja, Iadanza Alessandro, Salizzoni Stefano, Agrifoglio Marco, Nombela-Franco Luis, Bonaros Nikolaos, Kass Malek, Bruschi Giuseppe, Amabile Nicolas, Chhatriwalla Adnan, Messina Antonio, Hirji Sameer A, Andreas Martin, Welsh Robert, Schoels Wolfgang, Hellig Farrel, Windecker Stephan, Stortecky Stefan, Maisano Francesco, Stone Gregg W, Dvir Danny
Аннотация
METHODS: Patients undergoing mitral ViV and ViR were enrolled in the Valve-in-Valve International Data Registry. Cases were performed between March 2006 and March 2020. Clinical endpoints are reported according to the Mitral Valve Academic Research Consortium (MVARC) definitions. Significant residual mitral stenosis (MS) was defined as mean gradient ≥10 mm Hg and significant residual mitral regurgitation (MR) as ≥ moderate.
RESULTS: A total of 1079 patients (857 ViV, 222 ViR; mean age 73.5±12.5 years; 40.8% male) from 90 centers were included. Median STS-PROM score 8.6%; median clinical follow-up 492 days (interquartile range, 76-996); median echocardiographic follow-up for patients that survived 1 year was 772.5 days (interquartile range, 510-1211.75). Four-year Kaplan-Meier survival rate was 62.5% in ViV versus 49.5% for ViR (P<0.001). Mean gradient across the mitral valve postprocedure was 5.7±2.8 mm Hg (≥5 mm Hg; 61.4% of patients). Significant residual MS occurred in 8.2% of the ViV and 12.0% of the ViR patients (P=0.09). Significant residual MR was more common in ViR patients (16.6% versus 3.1%; P<0.001) and was associated with lower survival at 4 years (35.1% versus 61.6%; P=0.02). The rates of Mitral Valve Academic Research Consortium-defined device success were low for both procedures (39.4% total; 32.0% ViR versus 41.3% ViV; P=0.01), mostly related to having postprocedural mean gradient ≥5 mm Hg. Correlates for residual MS were smaller true internal diameter, younger age, and larger body mass index. The only correlate for residual MR was ViR. Significant residual MS (subhazard ratio, 4.67; 95% CI, 1.74-12.56; P=0.002) and significant residual MR (subhazard ratio, 7.88; 95% CI, 2.88-21.53; P<0.001) were both independently associated with repeat mitral valve replacement.
CONCLUSIONS: Significant residual MS and/or MR were not infrequent after mitral ViV and ViR procedures and were both associated with a need for repeat valve replacement. Strategies to improve postprocedural hemodynamics in mitral ViV and ViR should be further explored.