The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 1998
How drug resistance emerges as a result of poor compliance during short course chemotherapy for tuberculosis.
СтатьяНазвание и аннотация: Перевод в очереди
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Mitchison D A
Аннотация
OBJECTIVE: To explore mechanisms by which drug resistance might arise as a result of poor compliance during short course chemotherapy.
DESIGN: Four theoretical mechanisms are first described.
RESULTS: Examples of the way the mechanisms probably operate are taken from: 1) a study of once-weekly chemotherapy with streptomycin and isoniazid, and 2) the pattern of drug susceptibility in cultures from patients who relapsed after the end of treatment.
CONCLUSION: Good compliance is vitally important. The value of a fourth drug in the initial phase of chemotherapy in preventing resistance is questioned. An explanation for mono-resistance to rifampicin in patients with the acquired immune deficiency syndrome (AIDS) is suggested.
DESIGN: Four theoretical mechanisms are first described.
RESULTS: Examples of the way the mechanisms probably operate are taken from: 1) a study of once-weekly chemotherapy with streptomycin and isoniazid, and 2) the pattern of drug susceptibility in cultures from patients who relapsed after the end of treatment.
CONCLUSION: Good compliance is vitally important. The value of a fourth drug in the initial phase of chemotherapy in preventing resistance is questioned. An explanation for mono-resistance to rifampicin in patients with the acquired immune deficiency syndrome (AIDS) is suggested.
Предметные рубрики MeSH
AIDS-Related Opportunistic InfectionsAntibiotics, AntitubercularAntitubercular AgentsDrug Administration ScheduleDrug Resistance, MicrobialEthambutolHIV SeropositivityHumansIsoniazidMutationMycobacterium tuberculosisPatient CompliancePyrazinamideRecurrenceRifampinStreptomycinTuberculosis, Multidrug-ResistantTuberculosis, Pulmonary