Медицинская библиотека · The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 1998

How drug resistance emerges as a result of poor compliance during short course chemotherapy for tuberculosis.

Mitchison D A

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Аннотация

OBJECTIVE

To explore mechanisms by which drug resistance might arise as a result of poor compliance during short course chemotherapy.

DESIGN

Four theoretical mechanisms are first described.

RESULTS

Examples of the way the mechanisms probably operate are taken from: 1) a study of once-weekly chemotherapy with streptomycin and isoniazid, and 2) the pattern of drug susceptibility in cultures from patients who relapsed after the end of treatment.

CONCLUSION

Good compliance is vitally important. The value of a fourth drug in the initial phase of chemotherapy in preventing resistance is questioned. An explanation for mono-resistance to rifampicin in patients with the acquired immune deficiency syndrome (AIDS) is suggested.

Для цитирования: Mitchison D A. How drug resistance emerges as a result of poor compliance during short course chemotherapy for tuberculosis.. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 1998.

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