The Journal of laryngology and otology · 2025
Retrospective analysis of 351 patients with vocal fold leukoplakia: impact of smoking, lesion size and histopathological grade on treatment outcomes.
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Yang Xueqian, Peng Liang, Fang Ruihua, Chen Lin, Hu Zhangwei, Wang Dan, Ma Renqiang, Deng Jie, Zhu Xiaolin, Wang Zhangfeng, Wen Weiping, Lei Wenbin, Sun Wei
Аннотация
OBJECTIVE: To explore the treatment options and prognostic factors of vocal fold leukoplakia.
METHODS: The study examined conservative and surgical treatment approaches, and analysed prognostic factors influencing vocal fold leukoplakia outcomes.
RESULTS: In the conservative treatment group, lesion size (p = 0.035) and smoking (p < 0.001) were identified as independent factors influencing treatment outcomes. In the surgical treatment group, lesion size (p = 0.018) was identified as an independent factor affecting recurrence. There was no statistically significant difference in the effectiveness of conservative versus surgical treatment for patients with hyperplasia (p = 0.223), mild dysplasia (p = 0.634) and moderate dysplasia (p = 0.758).
CONCLUSION: Smoking and lesion size are key factors influencing the outcome of conservative treatment, while lesion size is a significant factor affecting recurrence in surgically treated patients. More importantly, conservative treatment should be prioritised for patients with moderate dysplasia and milder vocal fold leukoplakia.
METHODS: The study examined conservative and surgical treatment approaches, and analysed prognostic factors influencing vocal fold leukoplakia outcomes.
RESULTS: In the conservative treatment group, lesion size (p = 0.035) and smoking (p < 0.001) were identified as independent factors influencing treatment outcomes. In the surgical treatment group, lesion size (p = 0.018) was identified as an independent factor affecting recurrence. There was no statistically significant difference in the effectiveness of conservative versus surgical treatment for patients with hyperplasia (p = 0.223), mild dysplasia (p = 0.634) and moderate dysplasia (p = 0.758).
CONCLUSION: Smoking and lesion size are key factors influencing the outcome of conservative treatment, while lesion size is a significant factor affecting recurrence in surgically treated patients. More importantly, conservative treatment should be prioritised for patients with moderate dysplasia and milder vocal fold leukoplakia.