JACC. Case reports · 2025
Giant Coronary Artery Aneurysm in a Patient With Castleman Disease.
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Zia Abdul, Kim Morris M, Gill Sajan S, Sheikh Omar, Weller Samantha, Bhamipidipati Casti, Rahmouni Hind
Аннотация
BACKGROUND: Giant coronary artery aneurysms (CAAs), defined as aneurysms exceeding 20 mm, are rare vascular anomalies with potentially life-threatening complications such as thrombosis, embolization, and rupture. CCAs are typically linked to atherosclerosis and vasculitis, and their occurrence in Castleman disease (CD), a rare lymphoproliferative disorder, is exceedingly rare.
CASE SUMMARY: A 68-year-old man presented with a large right atrial mass on echocardiography, later identified on coronary computed tomography angiography and cardiac magnetic resonance imaging as a giant right coronary artery aneurysm with thrombus.
DISCUSSION: This case highlights a rare presentation of a giant CAA associated with CD and the potential role of interleukin-6 (IL-6) in aneurysm pathogenesis in CD. Additionally, this case underscores the importance of multimodal imaging in diagnosis and management. Further research is needed to explore the link between IL-6 dysregulation in CD and vascular abnormalities.
TAKE-HOME MESSAGES: CD may contribute to vascular abnormalities via IL-6-mediated inflammation. Multimodal imaging is essential for diagnosing giant CAAs and guiding appropriate intervention.
CASE SUMMARY: A 68-year-old man presented with a large right atrial mass on echocardiography, later identified on coronary computed tomography angiography and cardiac magnetic resonance imaging as a giant right coronary artery aneurysm with thrombus.
DISCUSSION: This case highlights a rare presentation of a giant CAA associated with CD and the potential role of interleukin-6 (IL-6) in aneurysm pathogenesis in CD. Additionally, this case underscores the importance of multimodal imaging in diagnosis and management. Further research is needed to explore the link between IL-6 dysregulation in CD and vascular abnormalities.
TAKE-HOME MESSAGES: CD may contribute to vascular abnormalities via IL-6-mediated inflammation. Multimodal imaging is essential for diagnosing giant CAAs and guiding appropriate intervention.