Infection and drug resistance · 2025
Successful Treatment of Extensively Drug-Resistant Acinetobacter baumannii Intracranial Infection with Meropenem and Cefoperazone Sodium Sulbactam: A Case Report.
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Ma Wenke, Zhang Chao, He Bei, Lv Xinwen, Luo Peng
Аннотация
BACKGROUND: Acinetobacter baumannii intracranial infections, especially those caused by multidrug-resistant (MDR) or extensively drug-resistant (XDR) strains, have posed an increasing challenge to treatment because of poor drug permeability through the blood-brain barrier (BBB) and increased bacterial drug resistance. Therefore, we aimed to explore a therapeutic schedule for Acinetobacter baumannii intracranial infection.
CASE PRESENTATION: We reported a case of intracranial infection caused by XDR A. baumannii after severe traumatic brain injury, cerebrospinal fluid (CSF) rhinorrhea, and severe pneumonia that was successfully treated with meropenem and cefoperazone sodium sulbactam.
CONCLUSION: This case illustrated that meropenem combined with cefoperazone sodium sulbactam could still be a therapeutic option against intracranial XDR A. baumannii infection.
CASE PRESENTATION: We reported a case of intracranial infection caused by XDR A. baumannii after severe traumatic brain injury, cerebrospinal fluid (CSF) rhinorrhea, and severe pneumonia that was successfully treated with meropenem and cefoperazone sodium sulbactam.
CONCLUSION: This case illustrated that meropenem combined with cefoperazone sodium sulbactam could still be a therapeutic option against intracranial XDR A. baumannii infection.