[Isoenzymes of transferases in serum from diphtheria patients].

AIM: Investigation of serum spectrum of isoenzymes AlAT, AsAT, GGT in diphtheria in adults.

MATERIALS AND

METHODS

The serum spectrum of cytoplasmic and mitochondrial isoenzymes AlAT, AsAT, GGT were studied in 12 bacterium carriers and 65 patients with diphtheria. Quite original evidence has been obtained on mechanism of hyperenzymemia.

RESULTS

Diphtheria is associated with enhanced activity of cytoplasmic isoenzymes in correlation with intoxication severity. Spectrum of isoenzymes AlAT and especially GGT shifted to the side of mitochondrial fractions. There were no statistically significant differences in the activity and spectrum of isoenzymes in myocarditis and in its absence. In clinical recovery the spectrum of isoenzyme activity remained changed.

CONCLUSION

It is suggested that dysisoenzymemia is related to active role of hepatocytes in utilization of diphtheria toxin, that carriers are not healthy people as hyperenzymemia is associated with morphological changes in the myocardium.