Ocular immunology and inflammation · 2005
Analysis of HLA class I and class II gene polymorphisms in Japanese patients with human T-cell lymphotropic virus type 1-associated uveitis.
Сравнительное исследованиеСтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Kaminagayoshi Tatsuhiko, Nakao Kumiko, Yashiki Shinji, Sonoda Shunro, Ohba Norio, Sakamoto Taiji
Аннотация
PURPOSE: To investigate the immunogenetic background of human T-cell lymphotropic virus type 1 (HTLV-1)-associated uveitis (HAU) that presents immune-mediated reactive changes in the uvea.
METHODS: HLA class I and class II genes were studied in 51 patients with HAU, 192 asymptomatic HTLV-1 carriers, and 266 HTLV-1-seronegative controls using a high-resolution method of HLA DNA typing. The HLA alleles of HAU were compared with those of HTLV-1 carriers and healthy controls.
RESULTS: We identified 62 distinct alleles of HLA-A, HLA-Cw, and HLA-B and 49 distinct alleles of HLA-DRB1 and HLA-DQB1 in patients with HAU, asymptomatic HTLV-1 carriers, and healthy controls. The relative frequencies of these HLA alleles did not differ among the three groups.
CONCLUSION: The results suggest that HLA class I and class II genes do not contribute to susceptibility to HAU.
METHODS: HLA class I and class II genes were studied in 51 patients with HAU, 192 asymptomatic HTLV-1 carriers, and 266 HTLV-1-seronegative controls using a high-resolution method of HLA DNA typing. The HLA alleles of HAU were compared with those of HTLV-1 carriers and healthy controls.
RESULTS: We identified 62 distinct alleles of HLA-A, HLA-Cw, and HLA-B and 49 distinct alleles of HLA-DRB1 and HLA-DQB1 in patients with HAU, asymptomatic HTLV-1 carriers, and healthy controls. The relative frequencies of these HLA alleles did not differ among the three groups.
CONCLUSION: The results suggest that HLA class I and class II genes do not contribute to susceptibility to HAU.
Предметные рубрики MeSH
AllelesAntibodies, ViralAsian PeopleDNAEye Infections, ViralGene FrequencyGenes, MHC Class IGenes, MHC Class IIGenetic Predisposition to DiseaseGenotypeHTLV-I InfectionsHistocompatibility TestingHuman T-lymphotropic virus 1HumansJapanPolymerase Chain ReactionPolymorphism, GeneticRetrospective StudiesUveitis