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DOI 10.1016/0962-8479(94)90099-x

Медицинская библиотека · Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 1994

Reduced sensitivity of tuberculosis serodiagnosis in patients with AIDS in Uganda.

Daniel T M, Sippola A A, Okwera A, Kabengera S, Hatanga E, Aisu T, Nyole S, Byekwaso F, Vjecha M, Ferguson L E

СтатьяПоддержка службы здравоохранения СШАПеревод в очереди

Аннотация

SETTING

The diagnostic utility of serodiagnosis of tuberculosis in HIV-infected persons was studied in Kampala, Uganda.

OBJECTIVE

This study was undertaken to evaluate the utility of a recently described serologic assay for the diagnosis of tuberculosis in HIV-infected patients.

DESIGN

The study was undertaken as a cross-sectional survey of 349 subjects, including human immunodeficiency virus-infected and uninfected patients with tuberculosis and control subjects. Serum from each subject was assayed by enzyme-linked immunosorbent assay (ELISA) for IgG antibody to the 30,000 dalton antigen of Mycobacterium tuberculosis.

RESULTS

Test sensitivity dropped from 0.62 in non HIV-infected tuberculous patients to 0.28 in HIV-infected patients.

CONCLUSIONS

ELISA serodiagnosis of tuberculosis may have a markedly decreased utility in populations where HIV infection is prevalent.

Для цитирования: Daniel T M, Sippola A A, Okwera A, Kabengera S, Hatanga E, Aisu T, Nyole S, Byekwaso F, Vjecha M, Ferguson L E. Reduced sensitivity of tuberculosis serodiagnosis in patients with AIDS in Uganda.. Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 1994. DOI: 10.1016/0962-8479(94)90099-x.

Предметные рубрики MeSH

AIDS-Related Opportunistic InfectionsAntibodies, BacterialCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayHumansImmunoglobulin GMycobacterium tuberculosisPredictive Value of TestsSensitivity and SpecificitySerologic TestsTuberculosis
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