Genetic variants of thioredoxin interacting protein gene and their association with diabetic peripheral neuropathy in type 2 diabetes mellitus.

AIMS: To investigate the association between genetic variants of the thioredoxin interacting protein (TXNIP) gene and diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus (T2DM).

METHODS

A total of 239 T2DM patients (144 in the DPN group and 95 in the T2DM-only group) and 283 healthy controls (NC group) were enrolled. Polymorphisms of TXNIP gene loci (rs7211, rs7212, rs4755, and rs9245) were analyzed.

RESULTS

The DPN group exhibited significantly higher frequencies of the AA genotype and A allele at the rs7211 locus compared to both the NC and T2DM groups (all P < 0.05). Similarly, the CC genotype and C allele at the rs7212 locus were more prevalent in the DPN group (all P < 0.05). Logistic regression analysis identified the AA genotype at rs7211 and the CC genotype at rs7212 as independent risk factors for DPN (all P < 0.05).

CONCLUSIONS

Polymorphisms at TXNIP rs7211 and rs7212 loci may contribute to genetic susceptibility to DPN in T2DM.