Transplant international : official journal of the European Society for Organ Transplantation · 2000
Normothermic recirculation reduces primary graft dysfunction of kidneys obtained from non-heart-beating donors.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Valero R, Cabrer C, Oppenheimer F, Trias E, Sánchez-Ibáñez J, De Cabo F M, Navarro A, Paredes D, Alcaraz A, Gutiérrez R, Manyalich M
Аннотация
Our aim was to analyze the short- and long-term function of kidneys procured from non- heartbeating donors (NHBD) by means of three techniques: in situ perfusion (ISP), total body cooling (TBC) and normothermic recirculation (NR). Fifty-seven potential NHBD were included. Mean warm ischemia time was 68.9 +/- 35.6 min. Forty-four kidneys were obtained from donors perfused with ISP, 8 with TBC, and 8 with NR. Eighteen kidneys (32%) started functioning immediately, 29 (52%) showed delayed graft function (DGF) and 9 (16%) showed primary non function (PNF). The actuarial graft survival rate was 76.4% at 1 year and 56% at 5 years. The patient survival rate was 89.3% at 5 years. Incidence of DGF and PNF was significantly lower in kidneys perfused with NR than those with ISP or TBC (P < 0.01). Duration of DGF was shorter in kidneys obtained through TBC than in kidneys obtained with ISP (P < 0.05). In conclusion, NR reduces the incidence of DGF and may be considered the method of choice for kidney procurement from NHBD.