Does vitamin B12 influence clinical pregnancy outcome in the follicular-phase GnRH agonist protocol?

PURPOSE: To investigate whether vitamin B12 levels affect IVF-ET pregnancy outcomes.

DESIGN

Single-center, retrospective, observational study.

DESIGN

Single-center, retrospective, observational study.

MAIN OUTCOME MEASURES: The primary outcome was the clinical pregnancy rate (CPR).

RESULTS

After adjusting for Age, BMI, AMH, number of oocytes retrieved, cleavage-stage embryos/blastocysts, and the number of transferred embryos, when the vitamin B12 value was ≤358.7 pg/ml, for every 10 pg/ml increase in the vitamin B12 value, the clinical pregnancy rate increased by 4% (OR=1.04, 95% CI=1.00, 1.08, P=0.03).

CONCLUSION

Within a specific range (≤358.7 pg/mL), serum vitamin B12 levels may modestly contribute to improved clinical pregnancy rates in women undergoing IVF-ET with the follicular-phase GnRH agonist protocol, though further validation is required to confirm its clinical significance.

TRIAL REGISTRATION: None.