Journal of affective disorders · 2026
Efficacy and safety of low-dose electroconvulsive therapy in adolescents with major depressive disorder and suicidal ideation in China: A prospective study with institutional historical control.
СтатьяКонтролируемое клиническое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Cai Haipeng, Du Ruonan, Li Wei, Hasen Qimuge, Wen Yaling, Zhou Jinwei, Zhang Yucong, Yu Yongjun, Wang Yanan, Wang Zhiren, Yang Kebing
Аннотация
OBJECTIVE: Currently, there are few studies on the efficacy and safety of lower dose electroconvulsive therapy (ECT) in adolescents with depressive mood and suicidal ideation. This study aims to investigate a preliminary exploration of lower dose ECT on improving depressive symptoms and suicidal ideation in adolescents with major depressive disorder (MDD), as well as to explore its impact on short-term cognitive function.
METHOD: This non-randomized controlled study compared a prospective intervention cohort receiving 8 sessions of low-dose ECT (n = 84) with a historical control cohort (n = 89) from the same institution that received antidepressant medication only. A1:1 propensity-score matching (PSM) approach was used to control for confounding factors between the two groups.
RESULTS: Compared to the control group, the ECT group showed significant improvements in the suicidal ideation from the end to 6 weeks after the treatment (p < 0.001) as well as improvements in depressive symptoms (p < 0.001). There was no significant statistical difference in short-term cognitive performance between the lower dose ECT group and the control group; however, the long-term effects of ECT on cognition remain to be elucidated.
CONCLUSIONS: This study preliminarily indicates that lower dose ECT may alleviate depressive symptoms and suicidal ideation in adolescents with MDD in the short term, and no serious adverse events were recorded during the treatment. No significant impairment in short-term cognitive function was observed in relation to lower dose ECT, but the long-term effects of ECT on cognitive function remain to be clarified.
METHOD: This non-randomized controlled study compared a prospective intervention cohort receiving 8 sessions of low-dose ECT (n = 84) with a historical control cohort (n = 89) from the same institution that received antidepressant medication only. A1:1 propensity-score matching (PSM) approach was used to control for confounding factors between the two groups.
RESULTS: Compared to the control group, the ECT group showed significant improvements in the suicidal ideation from the end to 6 weeks after the treatment (p < 0.001) as well as improvements in depressive symptoms (p < 0.001). There was no significant statistical difference in short-term cognitive performance between the lower dose ECT group and the control group; however, the long-term effects of ECT on cognition remain to be elucidated.
CONCLUSIONS: This study preliminarily indicates that lower dose ECT may alleviate depressive symptoms and suicidal ideation in adolescents with MDD in the short term, and no serious adverse events were recorded during the treatment. No significant impairment in short-term cognitive function was observed in relation to lower dose ECT, but the long-term effects of ECT on cognitive function remain to be clarified.