Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
Efficacy and safety of tACS in older adults with cognitive impairment: a systematic review and meta-analysis.
Систематический обзорСтатьяМетаанализНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ma Shenhong, Han Qiaohua, Zhang Di, Wang Heling, Zhuang Weisheng, Li Wanyue, Li Ying, Lei Beibei, Wang Yage
Аннотация
PURPOSE: To assess the safety and effectiveness of tACS as a therapeutic intervention for older adults with cognitive impairment.
MATERIALS AND METHODS: From the time of library construction until March 3, 2025, we conducted a comprehensive search of the databases PubMed, Embase, Web of Science and Cochrane Library. Additionally, we manually examined the references in the articles. The outcome indicators were cognitive function, which included memory function, attention, overall cognition, as well as safety.
RESULTS: 6 publications with a total of 888 subjects were included. The tACS group did better at treating cognitive impairment, especially memory problems (SMD = 0.7, 95% Cl = 0.29 to 1.12, I2 = 52%, P = 0.0009) and overall cognition (SMD = 1.97, 95% Cl = -0.87 to 3.06, I2 = 0%, P = 0.0004). However, it did not have good efficacy on attention. Furthermore, tACS was a very safe treatment.
CONCLUSIONS: tACS is very effective in the treatment of older adults with cognitive impairment, especially for memory function and overall cognition. In addition, tACS is a very safe treatment. However, in the future, there is still a need for many high-quality clinical studies on tACS for cognitive impairment.
MATERIALS AND METHODS: From the time of library construction until March 3, 2025, we conducted a comprehensive search of the databases PubMed, Embase, Web of Science and Cochrane Library. Additionally, we manually examined the references in the articles. The outcome indicators were cognitive function, which included memory function, attention, overall cognition, as well as safety.
RESULTS: 6 publications with a total of 888 subjects were included. The tACS group did better at treating cognitive impairment, especially memory problems (SMD = 0.7, 95% Cl = 0.29 to 1.12, I2 = 52%, P = 0.0009) and overall cognition (SMD = 1.97, 95% Cl = -0.87 to 3.06, I2 = 0%, P = 0.0004). However, it did not have good efficacy on attention. Furthermore, tACS was a very safe treatment.
CONCLUSIONS: tACS is very effective in the treatment of older adults with cognitive impairment, especially for memory function and overall cognition. In addition, tACS is a very safe treatment. However, in the future, there is still a need for many high-quality clinical studies on tACS for cognitive impairment.