C2BNet: A Deep Learning Architecture With Coupled Composite Backbone for Parasitic Egg Detection in Microscopic Images.

Internet of Medical Things (IoMT) enabled by artificial intelligence (AI) technologies can facilitate automatic diagnosis and management of chronic diseases (e.g., intestinal parasitic infection) based on 2D microscopic images. To improve model performance of object detection challenged by microscopic image characteristics (e.g., focus failure, motion blur, and whether zoomed or not), we propose coupled composite backbone network (C2BNet) to execute parasitic egg detection using 2D microscopic images. In particular, the C2BNet backbone adopts a two-path structure-based backbone and leverages model heterogeneity to learn object features from different perspectives. A novel feature composition style is proposed to flow features within the coupled composite backbone, and ensure mutual enhancement of feature representation ability among different paths of the backbone. To further improve the accuracy of detection results, we propose multiscale weighted box fusion (WBF) to fuse location and confidence scores of all bounding boxes predicted from multiscale feature maps, and iteratively refine box coordinates to form the final prediction. Experimental results on Chula-ParasiteEgg-11 dataset demonstrate that C2BNet not only performs satisfactorily compared with state-of-the-art methods, but also can focus more on learning detailed morphology features and abundant semantic features, resulting in more precise detection for parasitic eggs located in the 2D microscopic image.