Subconjunctival bevacizumab for corneal neovascularization.

OBJECTIVE

To report the efficacy of subconjunctival bevacizumab injection in patients with corneal neovascularization (NV).

METHODS

This retrospective interventional case study included two eyes of two patients with corneal NV due to aqueous-deficient dry eye with filamentary keratitis in the first case, and corneal graft failure in the second case. Patients received a subconjunctival injection of 2.5 mg (0.1 ml) bevacizumab. Morphologic changes were investigated by slit-lamp biomicroscopy and corneal photography.

RESULTS

Corneal NV was dramatically regressed a week after injection in the first case. In the second case, minor vessels were regressed while the major one did not. No infection or inflammation was observed. No relapse was seen within the follow-up of two to three months.

CONCLUSION

Subconjunctival injection of bevacizumab may offer an additional strategy for the treatment of corneal NV.