Медицинская библиотека · Head & neck · 2019

Anatomical subsite modifies survival in oropharyngeal squamous cell carcinoma: National Cancer Database study.

Tham Tristan, Ahn Seungjun, Frank Douglas, Kraus Dennis, Costantino Peter

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Аннотация

BACKGROUND

Oropharyngeal squamous cell carcinomas (OPSCC) can occur in either tonsillar related areas (TRA) or nontonsillar areas (nTRA). The prognostic differences between these sites are unclear. This study investigated this question using the National Cancer Database (NCDB), controlling for other confounders including human papillomavirus (HPV) status.

METHODS

This NCDB study was conducted by stratifying the HPV-positive oropharyngeal cancer cohort into two primary groups, TRA and nTRA. Kaplan Meier survival analysis was stratified according to HPV status, and further analysis was conducted using multivariable Cox regression.

RESULTS

A total of 23 297 patients were included in this study. In the multivariable cox regression analysis, OPSCC subsite was found to be an independent prognostic factor for survival (TRA vs nTRA HR: 0.76, 95% CI: 0.67-0.86, P < .0001).

CONCLUSION

In this large cohort, OPSCC subsite was found to be an independent prognostic factor for survival.

Для цитирования: Tham Tristan, Ahn Seungjun, Frank Douglas, Kraus Dennis, Costantino Peter. Anatomical subsite modifies survival in oropharyngeal squamous cell carcinoma: National Cancer Database study.. Head & neck. 2019. DOI: 10.1002/hed.26019.

Предметные рубрики MeSH

Carcinoma, Squamous Cell Head and Neck Neoplasms Humans Oropharyngeal Neoplasms Papillomavirus Infections Prognosis Squamous Cell Carcinoma of Head and Neck

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