[Research progress of extracellular matrix material for tissue engineering].

OBJECTIVE

To review the current research status and clinical application progress of extracellular matrix (ECM) material in tissue engineering.

METHODS

The literature about the latest progress in the preparation, biocompatibility, mechanical property, degradability, and clinical application of ECM material was extensively reviewed.

RESULTS

The improvement of the ECM preparation method and thorough understanding of the immunological properties have laid the foundation for the repair and reconstruction of the tissue. Moreover, a series of animal studies also confirm that the feasibility and effectiveness of the ECM such as small intestinal submucosa, bladder ECM grift, and acellular dermis which have been applied to the repair and reconstruction of the urethra, bladder, arteries, and skin tissue. It shows a wide prospect of clinical application in the future.

CONCLUSION

ECM material is a good bio-derived scaffold, which is expected to become an important source of alternative materials for the repair and reconstruction of the tissue.