Медицинская библиотека · Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2002

[An experimental study on the dermal substitute of spongy collagen membrane].

Yang Jun, Xiao Shichu, Xia Zhaofan

Аннотация на английскомСтатьяПеревод пока не подготовлен

Аннотация

OBJECTIVE

To investigate the practicability of a spongy collagen membrane as a dermal substitute.

METHODS

Porcine skin collagen was harvested and mixed and precipitated with chondroitin-6-sulfate, and then lyophilized for 48 hours to form sheets of highly porous membrane. The collagen membrane was embedded subcutaneously in SD rat's skin. The histological compatibility, the vascularization degree and degradation status were determined periodically by means of tissue sampling.

RESULTS

The collagen membrane possessed some degree of strength and tenacity with a structure consisting of multidinous interconnecting pores. It was easy to manipulate. Experimental subcutaneous embedding in SD rats indicated that the membrane exhibited good tissue compatibility, strong tendency to vascularization, with no evidence of acute inflammatory reaction, and slow degradation rate.

CONCLUSION

Spongy collagen membrane might be an optimal dermal substitute for wound coverage.

Для цитирования: Yang Jun, Xiao Shichu, Xia Zhaofan. [An experimental study on the dermal substitute of spongy collagen membrane].. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. 2002.

Предметные рубрики MeSH

Animals Collagen Dermatologic Surgical Procedures Rats Rats, Sprague-Dawley Skin Skin Transplantation Skin, Artificial Swine Tissue Engineering Transplantation, Heterologous

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