Retinal Optical Coherence Tomography in Neuromyelitis Optica.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Oertel Frederike Cosima, Specovius Svenja, Zimmermann Hanna G, Chien Claudia, Motamedi Seyedamirhosein, Bereuter Charlotte, Cook Lawrence, Lana Peixoto Marco Aurélio, Fontanelle Mariana Andrade, Kim Ho Jin, Hyun Jae-Won, Palace Jacqueline, Roca-Fernandez Adriana, Leite Maria Isabel, Sharma Srilakshmi, Ashtari Fereshteh, Kafieh Rahele, Dehghani Alireza, Pourazizi Mohsen, Pandit Lekha, D'Cunha Anitha, Aktas Orhan, Ringelstein Marius, Albrecht Philipp, May Eugene, Tongco Caryl, Leocani Letizia, Pisa Marco, Radaelli Marta, Martinez-Lapiscina Elena H, Stiebel-Kalish Hadas, Siritho Sasitorn, de Seze Jérome, Senger Thomas, Havla Joachim, Marignier Romain, Cobo-Calvo Alvaro, Bichuetti Denis, Tavares Ivan Maynart, Asgari Nasrin, Soelberg Kerstin, Altintas Ayse, Yildirim Rengin, Tanriverdi Uygur, Jacob Anu, Huda Saif, Rimler Zoe, Reid Allyson, Mao-Draayer Yang, Soto de Castillo Ibis, Petzold Axel, Green Ari J, Yeaman Michael R, Smith Terry, Brandt Alexander U, Paul Friedemann
Аннотация
METHODS: The cross-sectional Collaborative Retrospective Study on retinal optical coherence tomography (OCT) in neuromyelitis optica collected retrospective data from 22 centers. Of 653 screened participants, we included 283 AQP4-IgG-seropositive patients with NMOSD and 72 healthy controls (HCs). Participants underwent OCT with central reading including quality control and intraretinal segmentation. The primary outcome was thickness of combined ganglion cell and inner plexiform (GCIP) layer; secondary outcomes were thickness of peripapillary retinal nerve fiber layer (pRNFL) and visual acuity (VA).
RESULTS: Eyes with ON (NMOSD-ON, N = 260) or without ON (NMOSD-NON, N = 241) were assessed compared with HCs (N = 136). In NMOSD-ON, GCIP layer (57.4 ± 12.2 μm) was reduced compared with HC (GCIP layer: 81.4 ± 5.7 μm, p < 0.001). GCIP layer loss (-22.7 μm) after the first ON was higher than after the next (-3.5 μm) and subsequent episodes. pRNFL observations were similar. NMOSD-NON exhibited reduced GCIP layer but not pRNFL compared with HC. VA was greatly reduced in NMOSD-ON compared with HC eyes, but did not differ between NMOSD-NON and HC.
DISCUSSION: Our results emphasize that attack prevention is key to avoid severe neuroaxonal damage and vision loss caused by ON in NMOSD. Therapies ameliorating attack-related damage, especially during a first attack, are an unmet clinical need. Mild signs of neuroaxonal changes without apparent vision loss in ON-unaffected eyes might be solely due to contralateral ON attacks and do not suggest clinically relevant progression but need further investigation.