[Noninvasive pressure support ventilation (NIPSV) as therapy for severe respiratory insufficiency due to pulmonary edema].

OBJECTIVE

Experimental use of noninvasive pressure support ventilation (NIPSV) in patients with severe pulmonary oedema who would have been intubated if noninvasive ventilation were not available.

DESIGN

Open, prospective, within patients non comparative study.

SETTING

Internal intensive care unit (11 beds) at a university hospital.

PATIENTS: 29 patients with severe respiratory distress and confirmed pulmonary oedema.

INTERVENTIONS: NIPSV was applied via a tight fitting face mask delivering between 13 and 24 cm H2O inspiratory airway pressure and between 2 and 8 cm H2O expiratory airway pressure.

MEASUREMENTS AND

RESULTS

One patient required endotracheal intubation. Mean plethysmographic oxygen saturation rose significantly within 30 min from 73.8 +/- 11 to 90.3 +/- 5% while the oxygen supply was reduced from 7.3 +/- 3.7 to 5.1 +/- 3 l/min. Mean pH increased significantly (p < 0.01) from 7.22 +/- 0.1 before NIPSV to 7.31 +/- 0.01 after 60 min of NIPSV. Partial pressure of carbon dioxide was 62 +/- 18.5 mmHg, but decreased significantly within 60 min to 48.4 +/- 11.5 mm Hg. Heart rate and blood pressure established continuously during observation time. Mean duration of NIPSV was 6 h 9 min (range 120 min to 24 h). There were no serious side effects. Four patients died from underlying diseases between 1 and 28 days after NIPSV.

CONCLUSION

NIPSV is a highly effective technique with which to treat patients with severe cardiogenic pulmonary oedema.