The Journal of infectious diseases · 2010
Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDS.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Sezgin Efe, Jabs Douglas A, Hendrickson Sher L, Van Natta Mark, Zdanov Alexander, Lewis Richard Alan, Smith Michael W, Troyer Jennifer L, O'Brien Stephen J, SOCA Research Group
Аннотация
BACKGROUND: Cytomegalovirus (CMV) retinitis is a common opportunistic infection among patients with AIDS and still causes visual morbidity despite the wide spread usage of highly active antiretroviral therapy (HAART). The ubiquitous CMV pathogen contains a human interleukin-10 (IL-10) homolog in its genome and utilizes it to evade host immune reactions through an IL-10 receptor mediated immune-suppression pathway.
METHODS: Effects of IL-10R1, IL-10 and previously described AIDS restriction gene variants are investigated on the development of CMV retinitis in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) cohort (N = 1284).
RESULTS: In European Americans (n = 750), a haplotype carrying an amino acid changing variation in the cytoplasmic domain (S420L) of IL-10R1 can be protective (OR, 0.14; 95% CI, 0.02-0.94; P = .04) against, whereas another haplotype carrying an amino acid changing variation in the extracellular domain (I224V) of IL-10R1 can be more susceptible (OR, 6.21; 95% CI, 1.22- 31.54; P = .03) to CMV retinitis. In African Americans (n = 534), potential effects of IL-10 variants are observed.
CONCLUSION: Host genetics may have a role in the occurrence of CMV retinitis in patients infected with HIV.
METHODS: Effects of IL-10R1, IL-10 and previously described AIDS restriction gene variants are investigated on the development of CMV retinitis in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) cohort (N = 1284).
RESULTS: In European Americans (n = 750), a haplotype carrying an amino acid changing variation in the cytoplasmic domain (S420L) of IL-10R1 can be protective (OR, 0.14; 95% CI, 0.02-0.94; P = .04) against, whereas another haplotype carrying an amino acid changing variation in the extracellular domain (I224V) of IL-10R1 can be more susceptible (OR, 6.21; 95% CI, 1.22- 31.54; P = .03) to CMV retinitis. In African Americans (n = 534), potential effects of IL-10 variants are observed.
CONCLUSION: Host genetics may have a role in the occurrence of CMV retinitis in patients infected with HIV.
Предметные рубрики MeSH
AIDS-Related Opportunistic InfectionsAcquired Immunodeficiency SyndromeAdultBlack or African AmericanCytomegalovirus RetinitisFemaleGene FrequencyGenetic Predisposition to DiseaseHumansImmunity, InnateInterleukin-10Interleukin-10 Receptor alpha SubunitLongitudinal StudiesMaleMiddle AgedPolymorphism, GeneticUnited StatesWhite People