Frontiers in cardiovascular medicine · 2025
Predictive value of postoperative prealbumin levels for detecting early-stage complications following off-pump coronary artery bypass grafting.
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Jia Yanting, Zhang Jun, Chen Lei, Zhu Yanhui
Аннотация
BACKGROUND: A pathological decrease in the serum prealbumin level is closely associated with the severity of various diseases and complications after surgery. Many patients suffer from a systemic inflammatory response and local myocardial ischemia after off-pump coronary artery bypass grafting, which is related to an adverse prognosis. This study aimed to explore the relationship between the serum prealbumin level and early complications following off-pump coronary artery bypass grafting, in addition to its predictive value.
METHODS: Data were retrospectively collected on patients undergoing off-pump coronary artery bypass grafting from January 2014 to July 2019. The serum prealbumin level was assessed within 6-12 h after the operation. Patients were classified into two groups: the "normal" level group (≥17 mg/dl) and the "low" level group (<17 mg/dl). Univariate and multivariable analyses were performed to evaluate the predictive value of a low serum prealbumin level.
RESULTS: Of the 1,002 patients, 553 (55.2%) had a low serum prealbumin level. The rate of pulmonary infection in the low group was significantly higher than in the normal group. Univariate analysis and multivariable analysis indicated that a low serum prealbumin level was associated with the increased incidence of postoperative pulmonary infection, pleural effusion, and new-onset atrial fibrillation.
CONCLUSION: The serum prealbumin level following off-pump coronary artery bypass grafting serves as a crucial predictor for early major postoperative complications, such as pulmonary complications and new-onset atrial fibrillation. Early identification of high-risk patients by assessing serum prealbumin levels, in addition to the timely adjustment of treatment and care strategies, can improve patient prognosis, shorten hospital stays, and reduce healthcare expenses.
METHODS: Data were retrospectively collected on patients undergoing off-pump coronary artery bypass grafting from January 2014 to July 2019. The serum prealbumin level was assessed within 6-12 h after the operation. Patients were classified into two groups: the "normal" level group (≥17 mg/dl) and the "low" level group (<17 mg/dl). Univariate and multivariable analyses were performed to evaluate the predictive value of a low serum prealbumin level.
RESULTS: Of the 1,002 patients, 553 (55.2%) had a low serum prealbumin level. The rate of pulmonary infection in the low group was significantly higher than in the normal group. Univariate analysis and multivariable analysis indicated that a low serum prealbumin level was associated with the increased incidence of postoperative pulmonary infection, pleural effusion, and new-onset atrial fibrillation.
CONCLUSION: The serum prealbumin level following off-pump coronary artery bypass grafting serves as a crucial predictor for early major postoperative complications, such as pulmonary complications and new-onset atrial fibrillation. Early identification of high-risk patients by assessing serum prealbumin levels, in addition to the timely adjustment of treatment and care strategies, can improve patient prognosis, shorten hospital stays, and reduce healthcare expenses.