Photodiagnosis and photodynamic therapy · 2017
Pemphigus vulgaris induced by 5-aminolaevulinic acid-based photodynamic therapy.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Zhou Qian, Wang Peiru, Zhang Linglin, Wang Bo, Shi Lei, Keyal Uma, Bhatta Anil Kumar, Zhang Guolong, Wang Xiuli
Аннотация
Pemphigus vulgaris (PV) is an autoimmune disorder resulting from the interaction between autoantibodies and desmoglein. Here, we report a case of PV developed after 5-aminolaevulinic acid-based photodynamic therapy (ALA-PDT). The harmful and deleterious effects of UV radiation on the onset, during course, and perpetuation of PV have been observed for decades. Correlation between reactive oxygen species (ROS) and PV have also been reported. Oxidative proteins, which are modified by ROS, and subsequent production of antibodies by immune system seem to be responsible for PV developed following ALA-PDT. We emphasize that ALA-PDT should be added to the list of possible factors triggering PV and this condition should be considered if blistering arises following ALA-PDT.