Progress toward understanding the molecular mechanisms of neurotrophic factor signalling.

Understanding the mechanism of action of the neurotrophic factors is central to unravelling of the mysteries of some of the neurodegenerative disorders. In this review we will discuss recent advances in our understanding of neurotrophic factor signalling in primary cultured neurons, in particular those from the superior cervical and dorsal root ganglia, as well as cerebellar granule cells, cortical neurons and oligodendrocytes.