Archives of neurology · 2001
Increase in peripheral CD4 bright+ CD8 dull+ T cells in Parkinson disease.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Hisanaga K, Asagi M, Itoyama Y, Iwasaki Y
Аннотация
BACKGROUND: Immune abnormalities are known to be involved in the pathogenesis of sporadic Parkinson disease.
OBJECTIVE: To examine whether abnormalities in peripheral lymphocytes exist in Parkinson disease.
METHODS: Immune mediators, including CD1a, CD3, CD4, CD8, CD45RO, and Fas (CD95), were examined in peripheral lymphocytes of patients by 3-color flow cytometry.
RESULTS: Patients with Parkinson disease displayed a significantly greater population of circulating CD3+ CD4 bright+ CD8 dull+ lymphocytes than age-matched control subjects (P =.005) and patients with cerebrovascular disease (P =.002). The increase in these cells appeared to continue for at least 17 months. These T cells also expressed CD45RO and Fas, markers for activated T cells, while CD1a, a marker for thymic T cells, was negative, suggesting that these cells are mature T cells with immune activities.
CONCLUSIONS: As CD4+ CD8+ T cells are known to increase after some specific viral infections, the continuous increase in CD4 bright+ CD8 dull+ T cells shown here may indicate postinfectious immune abnormalities that are possibly associated with the pathogenesis of this slowly progressive, multifactorial neurodegenerative disease.
OBJECTIVE: To examine whether abnormalities in peripheral lymphocytes exist in Parkinson disease.
METHODS: Immune mediators, including CD1a, CD3, CD4, CD8, CD45RO, and Fas (CD95), were examined in peripheral lymphocytes of patients by 3-color flow cytometry.
RESULTS: Patients with Parkinson disease displayed a significantly greater population of circulating CD3+ CD4 bright+ CD8 dull+ lymphocytes than age-matched control subjects (P =.005) and patients with cerebrovascular disease (P =.002). The increase in these cells appeared to continue for at least 17 months. These T cells also expressed CD45RO and Fas, markers for activated T cells, while CD1a, a marker for thymic T cells, was negative, suggesting that these cells are mature T cells with immune activities.
CONCLUSIONS: As CD4+ CD8+ T cells are known to increase after some specific viral infections, the continuous increase in CD4 bright+ CD8 dull+ T cells shown here may indicate postinfectious immune abnormalities that are possibly associated with the pathogenesis of this slowly progressive, multifactorial neurodegenerative disease.
Предметные рубрики MeSH
AdultAgedAntiparkinson AgentsCD4 Lymphocyte CountCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedCerebrovascular DisordersCytomegalovirusDiagnosis, DifferentialFemaleFlow CytometryHIVHerpesvirus 4, HumanHerpesvirus 6, HumanHumansImmunologic MemoryImmunophenotypingKidney TransplantationLymphocyte CountMaleMyasthenia GravisParkinson DiseaseReference ValuesT-Lymphocytes, CytotoxicThymus Gland