Glycopeptide Heteroresistance Among Coagulase-Negative Staphylococci: A Systematic Review and Meta-analysis.

We identified a high prevalence of glycopeptide heteroresistance amongst coagulase-negative staphylococci (41.4%, 95% confidence interval 30.7-52.9; meta-analysis including n = 1432 isolates). Heteroresistance was associated with methicillin resistance, did not require glycopeptide exposure, and may be more prevalent among isolates from invasive infections. Heteroresistance may represent an under-appreciated reason for treatment failure of CoNS infections.