Impact of HLA-B51 on Uveitis and Retinal Vasculitis: Data from the AIDA International Network Registries on Ocular Inflammatory Disorders.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Sota Jurgen, Guerriero Silvana, Lopalco Giuseppe, Tufan Abdurrahman, Ragab Gaafar, AlMaglouth Ibrahim, Govoni Marcello, Sfikakis Petros P, Frassi Micol, Vitale Antonio, Kardas Riza Can, Triggianese Paola, Chimenti Maria Sole, Aboabat Aos A, Piga Matteo, Monti Sara, Sebastiani Gian Domenico, Yildirim Derya, Conforti Alessandro, Gentileschi Stefano, Dammacco Rosanna, Hinojosa-Azaola Andrea, Kawakami-Campos Perla Ayumi, Ruffilli Francesca, Torres-Ruiz Jiram, Thabet Maissa, Atig Amira, Ruscitti Piero, Cataldi Giulia, Viapiana Ombretta, Hatemi Gülen, Karakoç Alican, Costi Stefania, Iagnocco Annamaria, Crisafulli Francesca, Fragoulis George, Del Giudice Emanuela, Hegazy Mohamed Tharwat, Paroli Maria Pia, Şahin Ali, Morrone Maria, Iannone Florenzo, Opris-Belinski Daniela, Asfina Kazi Nur, Barone Patrizia, Gaggiano Carla, Kucuk Hamit, Gicchino Maria Francesca, Carubbi Francesco, Caggiano Valeria, Laskari Katerina, Tharwat Samar, Direskeneli Haner, Alibaz-Oner Fatma, Sevik Gizem, Maier Armin, Laymouna Ahmed Hatem, Emmi Giacomo, Akkoç Nurullah, Tarsia Maria, Sbalchiero Jessica, Conti Giovanni, Spinella Rosaria, La Torre Francesco, Tombetti Enrico, Amin Rana Hussein, Mauro Angela, Karamanakos Anastasios, Carreño Ester, Fonollosa Alex, Cattalini Marco, Breda Luciana, de-la-Torre Alejandra, Wiesik-Szewczyk Ewa, Cifuentes-González Carlos, Ozen Seza, Mazzei Maria Antonietta, Tosi Gian Marco, Frediani Bruno, Balistreri Alberto, Batu Ezgi Deniz, Gupta Vishali, Cantarini Luca, Fabiani Claudia
Аннотация
METHODS: Data were prospectively collected from the International AIDA Network Registry for BD and for NIU. We assessed differences between groups (NIU unrelated to BD and positive for HLA-B51, BD-related uveitis positive for HLA-B51 and BD-related uveitis negative for HLA-B51) in terms of long-term ocular complications, visual acuity (VA) measured by best corrected visual acuity (BCVA), anatomical pattern, occurrence of retinal vasculitis (RV) and macular edema over time.
RESULTS: Records of 213 patients (341 eyes) were analyzed. No differences in complications were observed (p = 0.465). With regard to VA, a significant difference was detected in median BCVA (p = 0.046), which was not maintained after Bonferroni correction (p = 0.060). RV was significantly more prevalent in NIU-affected patients who tested positive for HLA-B51, irrespective of the systemic diagnosis of BD (p = 0.025). No differences emerged in the occurrence of macular edema (p = 0.99).
CONCLUSIONS: Patients with NIU testing positive for HLA-B51 exhibit an increased likelihood of RV throughout disease course, irrespective of a systemic diagnosis of BD. The rate of complications as well as VA are comparable between NIU cases unrelated to BD testing positive for HLA-B51 and uveitis associated with BD. Therefore, it is advisable to perform the HLA-B typing in patients with NIU or retinal vasculitis, even in the absence of typical BD features.