Cold Hands, Warm Heart: Quality of life, wellbeing, and mental health in Raynaud's disease - An international survey study.

The study assessed quality of life, wellbeing, and mental health in individuals living with Raynaud's disease (RD), using a large international sample (n = 720). Participants completed Raynaud-Specific Quality of Life Questionnaire (RQLQ), WHO-5 Wellbeing Index, DASS-21 and demographics. Meteorological variables were recorded based on location. Participants with secondary RD reported lower quality of life and wellbeing, and higher anxiety, depression, and pain, than participants with primary RD or without a diagnosis. Participants without a diagnosis reported worse mental health than groups with a diagnosis. Participants in tropical climates reported the lowest quality of life, and those in temperate climates had the lowest wellbeing. Pain and symptom severity were the strongest predictors of quality of life. RD negatively affects quality of life, wellbeing, and mental health, particularly in secondary RD. Pain and symptom severity are key determinants. Meteorological factors contribute minimally. Tailored interventions focusing on symptom management should be prioritised.