Dermatology (Basel, Switzerland) · 2005
Three cases of transition from pemphigus vulgaris to pemphigus foliaceus confirmed by desmoglein ELISA.
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Ng Patricia Pei Lin, Thng Steven Tien Guan
Аннотация
We report 3 cases of pemphigus vulgaris (PV) confirmed by histology and direct and indirect immunofluorescence that showed transition to pemphigus foliaceus (PF) 2-4 years from the time of disease onset. Desmoglein (Dsg) ELISA testing of the sera from these 3 patients in the later stages of their disease showed the presence of anti-Dsg1 antibodies and the absence of anti-Dsg3 antibodies. These patients were on prednisolone and immunosuppressives at the time the sera were tested, and it is unclear if the transition from PV to PF is a permanent one or whether it is due to preferential suppression of Dsg3 antibodies below a certain threshold. Previously reported cases of transition from PV to PF and PF to PV are summarized.
Предметные рубрики MeSH
AdultBiopsy, NeedleCytoskeletal ProteinsDesmoglein 1DesmogleinsDesmoplakinsDisease ProgressionEnzyme-Linked Immunosorbent AssayFemaleFluorescent Antibody Technique, DirectFluorescent Antibody Technique, IndirectFollow-Up StudiesHumansImmunohistochemistryImmunosuppressive AgentsMaleMiddle AgedPemphigusSampling StudiesSensitivity and SpecificitySeverity of Illness Index