Drug development and industrial pharmacy · 2026
Recent advances in cationic material integration for enhanced antimicrobial formulations.
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Salatin Sara, Ahmadi Shirin, Abedi Ghobadloo Parvin, Azarfarin Maryam, Hamidi Samin
Аннотация
OBJECTIVE: To review recent advances in cationic antimicrobial systems - including surfactants, polymers, peptides, quaternary ammonium-based materials, and ionic-liquid-derived agents - and to summarize emerging strategies aimed at combating antibiotic-resistant bacteria.
SIGNIFICANCE OF REVIEW: Cationic antimicrobial compounds provide a promising alternative to traditional antibiotics due to their membrane-disruptive action mediated by electrostatic interactions. This mechanism enables broad-spectrum activity while reducing the potential for resistance development.
KEY FINDINGS: A comprehensive evaluation of recent literature reveals substantial progress across multiple cationic antimicrobial platforms. Enhanced surfactants with improved membrane-disrupting efficiency, advanced cationic polymer architectures with greater biocompatibility, and engineered antimicrobial peptides (AMPs) with tunable properties have been reported. Furthermore, quaternary ammonium-based polymeric systems and rapidly expanding ionic-liquid antimicrobials demonstrate significant potential for diverse therapeutic and material applications.
CONCLUSIONS: Cationic antimicrobial agents are advancing through varied chemical designs and formulation strategies, offering effective tools against resistant bacterial strains. Continued innovation across surfactant, polymer, peptide, and ionic-liquid systems highlights their increasing promise for both clinical and industrial implementation.
SIGNIFICANCE OF REVIEW: Cationic antimicrobial compounds provide a promising alternative to traditional antibiotics due to their membrane-disruptive action mediated by electrostatic interactions. This mechanism enables broad-spectrum activity while reducing the potential for resistance development.
KEY FINDINGS: A comprehensive evaluation of recent literature reveals substantial progress across multiple cationic antimicrobial platforms. Enhanced surfactants with improved membrane-disrupting efficiency, advanced cationic polymer architectures with greater biocompatibility, and engineered antimicrobial peptides (AMPs) with tunable properties have been reported. Furthermore, quaternary ammonium-based polymeric systems and rapidly expanding ionic-liquid antimicrobials demonstrate significant potential for diverse therapeutic and material applications.
CONCLUSIONS: Cationic antimicrobial agents are advancing through varied chemical designs and formulation strategies, offering effective tools against resistant bacterial strains. Continued innovation across surfactant, polymer, peptide, and ionic-liquid systems highlights their increasing promise for both clinical and industrial implementation.