Bulletin of experimental biology and medicine · 2018
Expression of Genes Encoding Cell Motility Proteins during Progression of Head and Neck Squamous Cell Carcinoma.
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Kakurina G V, Kondakova I V, Spirina L V, Kolegova E S, Shashova E E, Cheremisina O V, Novikov V A, Choinzonov E L
Аннотация
The model of head and neck squamous cell carcinoma (HNSCC) was used to study the expression of genes encoding actin-binding proteins depending on the type of cell motility. The expression of SNAIL1 and CAPN2 mRNA in HNSCC tissue was higher than in specimens of dysplastic epithelium of the larynx and hypopharynx, which can be explained by activation of mesenchymal and amoeboid types of cell motility. In biopsy material of HNSCC patients with T1-2N0M0, expression of genes responsible for actin-binding proteins differed from that of patients with pretumor pathology of the larynx and hypopharynx: expression of FSCN was lower, while expressions of EZR and CAP1 were higher. The data attest that progression of HNSCC is associated with activation of both types of cell motility and with the changes in the expression of mRNA encoding cell motility proteins.
Предметные рубрики MeSH
CalpainCarrier ProteinsCell Cycle ProteinsCell Line, TumorCell MovementCofilin 1Cytoskeletal ProteinsDisease ProgressionFemaleGene Expression Regulation, NeoplasticHead and Neck NeoplasmsHumansHypopharynxLarynxMaleMicrofilament ProteinsMiddle AgedProfilinsSignal TransductionSnail Family Transcription FactorsSquamous Cell Carcinoma of Head and NeckVimentinrho GTP-Binding ProteinsEzrin