Comparison of Effectiveness and Safety of Microwave Ablation of Colorectal Liver Metastases Adjacent versus Nonadjacent to the Diaphragm.

PURPOSE: To compare the effectiveness and safety of percutaneous microwave ablation (MWA) for colorectal liver metastasis (CLM) adjacent versus nonadjacent to the diaphragm.

MATERIALS AND

METHODS

This was a retrospective analysis of a prospectively created MWA database, from 2 prospective clinical trials for patients with CLM treated in a single tertiary center from 2012 to 2023. CLM adjacent to the diaphragm was defined as a tumor located <1 cm from the diaphragm. Minimal ablation margin (MM) was calculated with 3-dimensional software using postablation contrast-enhanced computed tomography (CT). Adverse events were assessed with Common Terminology Criteria for Adverse Events (CTCAE) v5.0 classification for 6 months.

RESULTS

Two hundred nine CLMs underwent 191 MWA sessions in 143 patients. Mean tumor diameter was 1.52 cm (SD ± 0.53). Eighty-three of 209 (39.7%) CLMs were adjacent to the diaphragm. There was no difference in local tumor progression-free survival (LTPFS) between CLMs adjacent and nonadjacent to the diaphragm (hazard ratio [HR], 0.65; 95% CI, 0.37-1.16; P = .15). MMs of 5-10 mm and >10 mm were documented in 49.3% versus 46.8% (P = .83) and 21.6% versus 12.6% (P = .16) for CLMs adjacent versus nonadjacent to the diaphragm, respectively. Twelve-month LTPFS was similar between groups (HR, 0.65; 95% CI, 0.37-1.16; P = .15) without local tumor progression for MM of >10 mm. There were 3 Grade IV adverse events: 1 diaphragmatic perforation, 1 liver abscess, and 1 biloma. Pneumothorax was associated with location adjacent to the diaphragm (P < .001) and transpulmonary approach (P < .001). Median length of hospital stay was 2 days (interquartile range [IQR], 1-3 days) for patients who needed thoracostomy (n = 20, 9.6%) compared with 1 day (IQR, 1-8 days) for those who did not, without long-term sequelae.

CONCLUSIONS

MWA of CLM adjacent to the diaphragm is effective and safe, without difference in success and 12-month LTPFS. Pneumothorax was associated with location adjacent to the diaphragm and thoracostomy that resulted in longer hospitalization without long-term sequelae.