First Presentation of Atherosclerotic Cardiovascular Disease in Previously Healthy Individuals.

PURPOSE OF REVIEW: To review studies evaluating the first presentation of atherosclerotic cardiovascular disease in previously asymptomatic individuals. RECENT FINDINGS: Prior studies have evaluated the first presentation of a broad range of CVD events. In a recent study from the Multi-Ethnic Study of Atherosclerosis, ASCVD events were evaluated specifically in a population of previously asymptomatic individuals. Death/resuscitated cardiac arrest was the most common first presentation, and this disproportionately affected women and Black individuals. CAC scoring was identified as a potential tool to identify individuals at risk. The first presentation of ASCVD is often severe, including death. This emphasizes the need for risk assessment and preventive therapies in appropriate individuals.