The journal of obstetrics and gynaecology research · 2025
The effect of dolutegravir on obstetrical outcomes among women living with HIV: A retrospective cohort study.
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Al Naimi Ammar, Chang Charlotte, Rawizza Holly, Olaifa Oluwaseun, Ogunsola Olabanjo, Okonkwo Prosper, Kanki Phyllis
Аннотация
OBJECTIVE: To assess the effect of dolutegravir (DTG) on obstetrical outcomes for women living with HIV (WLWH).
METHODS: This retrospective cohort study evaluated adult WLWH in antenatal care between 2016 and 2022 at two Nigerian centers. Patients were stratified into three antiretroviral therapy (ART) exposure groups: non-DTG ART, DTG-switch, and DTG. Multivariate linear and logistic regression models were utilized to assess the association between the type of ART and gestational weight gain (GWG), small for gestational age (SGA), gestational hypertension, and preterm birth.
RESULTS: The study included 1839 (77.1%) non-DTG users, 359 (15%) DTG users, and 188 (7.9%) DTG switchers. The adjusted association between DTG exposure and GWG was 0.72 (-0.08, 1.53) kg and 0.51 (-0.51, 1.54) kg for the DTG and DTG-switch groups, respectively, compared to other ARTs. The adjusted odds ratios for gestational hypertension were 0.47 (0.09, 2.49) and 1.31 (0.43, 4.02), 0.57 (0.22, 1.52) and 0.73 (0.25, 2.10) for preterm birth, and 0.55 (0.25, 1.20) and 0.26 (0.08, 0.83) for SGA in DTG and DTG-switch, respectively, compared to other ARTs.
CONCLUSIONS: DTG therapy is not associated with the risk of gestational hypertension nor preterm birth, and antenatal ART switching to DTG decreases the risk of growth restriction.
METHODS: This retrospective cohort study evaluated adult WLWH in antenatal care between 2016 and 2022 at two Nigerian centers. Patients were stratified into three antiretroviral therapy (ART) exposure groups: non-DTG ART, DTG-switch, and DTG. Multivariate linear and logistic regression models were utilized to assess the association between the type of ART and gestational weight gain (GWG), small for gestational age (SGA), gestational hypertension, and preterm birth.
RESULTS: The study included 1839 (77.1%) non-DTG users, 359 (15%) DTG users, and 188 (7.9%) DTG switchers. The adjusted association between DTG exposure and GWG was 0.72 (-0.08, 1.53) kg and 0.51 (-0.51, 1.54) kg for the DTG and DTG-switch groups, respectively, compared to other ARTs. The adjusted odds ratios for gestational hypertension were 0.47 (0.09, 2.49) and 1.31 (0.43, 4.02), 0.57 (0.22, 1.52) and 0.73 (0.25, 2.10) for preterm birth, and 0.55 (0.25, 1.20) and 0.26 (0.08, 0.83) for SGA in DTG and DTG-switch, respectively, compared to other ARTs.
CONCLUSIONS: DTG therapy is not associated with the risk of gestational hypertension nor preterm birth, and antenatal ART switching to DTG decreases the risk of growth restriction.
Предметные рубрики MeSH
HumansFemalePregnancyPyridonesHeterocyclic Compounds, 3-RingOxazinesRetrospective StudiesAdultHIV InfectionsPiperazinesHIV Integrase InhibitorsPremature BirthPregnancy OutcomePregnancy Complications, InfectiousGestational Weight GainHypertension, Pregnancy-InducedInfant, NewbornInfant, Small for Gestational AgeDolutegravir