Botulinum toxin-A injection may be beneficial in the treatment of life-long premature ejaculation.

Although premature ejaculation (PE) is a very common male sexual dysfunction there is still no European Medicines Agency (EMEA) or Food and Drug Administration (FDA) approved pharmacological treatment developed for this disease. Ejaculation is a spinal cord reflex where bulbospongiosus and ischiocavernosus muscles play the primary roles. The latest articles provided us that, life-long PE is presumed to have an underlying neurobiological pathophysiology and thus medical therapy would be superior to psychotherapy. Therefore, we hypothesize that the inhibition of the stereotyped rhythmic contractions of these muscles via the injection of botulinum toxin type A, we may have a beneficial effect in treatment of life-long PE.